Sanadihii la soo dhaafay, cilmi-baarista ku saabsanBenzylamino Acids(Benzylation of Amino Acids) ayaa soo jiidatay dareen baahsan.Benzylamino acid waa hab kiimikaad isku-dhafan, kaas oo ku gaadhi kara isbeddelo shaqayneed iyadoo la gelinayo kooxaha benzyl molecules amino acid, wuxuuna leeyahay rajooyin ballaadhan.Amino acids waa unugyada asaasiga ah ee borotiinnada, hantidooda iyo qaab-dhismeedkooduna waxay muhiim u yihiin shaqada borotiinnada.Soo bandhigida kooxaha benzyl, sifooyinka physicochemical ee molecules amino acid waa la bedeli doonaa, taas oo kordhinaysa codsigeeda dhinacyada daawada, sayniska alaabta iyo iskudhafka organic.
Dhinaca daawada, cilmi-baarista phenylmethyl amino acid ayaa si ballaaran loogu isticmaalaa isku-darka daroogada.Awoodeeda lagu soo bandhigo kooxaha benzyl waxay siisaa molecules daroogada qaab dhismeed deggan iyo fursad ay ku wanaajiso nuugitaankooda.Hydrophilicity iyo milanka dufan ee molecules daroogada waxaa lagu hagaajin karaa iyadoo la soo bandhigayo kooxaha benzyl, taas oo kor u qaadeysa dhaqdhaqaaqooda farmasiga iyo noolaha.Tani waxay siinaysaa fursado badan oo loogu talagalay horumarinta dawooyinka cusub waxayna kor u qaadaysaa hal-abuurnimada iyo horumarka dhinaca daawada.Intaa waxaa dheer, phenylmethylamic acid sidoo kale waxay leedahay codsiyo ballaaran oo suurtagal ah oo ku saabsan sayniska qalabka.
Iyada oo la xakameynayo xaaladaha isku-dhafka, walxaha polymer ee leh hawlo gaar ah ayaa la diyaarin karaa.Soo bandhigida kooxaha benzyl waxay hagaajin karaan dhaqdhaqaaqa dusha sare iyo sifooyinka farsamada ee alaabta, taas oo hagaajinaysa waxqabadka iyo shaqada alaabta.Tani waxay saameyn muhiim ah ku leedahay horumarinta goobaha sida alaabta batteriga, kicinta iyo dareemayaasha.Intaa waxaa dheer, horumarinta habka amino acid p-benzyl ayaa sidoo kale door muhiim ah ka ciyaara isku-dhafka dabiiciga ah.Isticmaalka habkan, cilmi-baarayaashu waxay si sax ah u beddeli karaan qaabka molecules amino acid si ay u abuuraan xeryahooda organic leh hawlo gaar ah, sida dhexdhexaadinta daroogada iyo molecules functional.Tani waxay siisaa madal ballaadhan oo loogu talagalay kimistariga synthetic organic waxayna kor u qaadaysaa horumarka dheeraadka ah ee kimistariga dabiiciga ah.
Waqtigan xaadirka ah, taxane guulo muhiim ah ayaa lagu sameeyay cilmi baarista p-phenylmethylamino acid.Dhinaca kale, marka la eego hababka isku-dhafka, cilmi-baarayaashu waxay si joogto ah u wanaajiyaan xaaladaha falcelinta iyo hababka kicinta si loo hagaajiyo waxtarka falcelinta iyo xulashada.Dhanka kale, marka la eego goobaha codsiga, habka phenylmethylamino acid ayaa si weyn loogu isticmaalay daahfurka daroogada iyo sayniska maadada, waxayna ku guuleysteen natiijooyin taxane ah oo muhiim ah.Eray ahaan, cilmi baarista iyo codsiga p-phenylmethylamino acid waxay wax ka tari doontaa horumarinta sayniska iyo tignoolajiyada.Codsiga hal-abuurka leh ee habkani ma aha oo kaliya inuu kor u qaado horumarinta goobta daawada, laakiin sidoo kale wuxuu keenaa horumarro cusub iyo hal-abuurnimo dhinacyada sayniska qalabka iyo isku-dhafka organic.Waxaa la rumeysan yahay in dadaalka cilmi-baarayaal badan, codsiga phenylmethylamino acid uu muujin doono rajo ballaaran mustaqbalka.
Waqtiga boostada: Agoosto-10-2023
